Autologous Hematopoietic Stem Cell Transplantation Hsct

Autologous hematopoietic stem cell transplantation also known as stem cell therapy or by the acronym ahsct is an emerging yet controversial treatment method for multiple sclerosis ms. This article explores the process of. Hematopoietic stem cell transplantation hsct involves the intravenous iv infusion of autologous or allogeneic stem cells to reestablish hematopoietic function in patients whose bone marrow or immune system is damaged or defective.

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Hematopoietic stem cell transplantation hsct is the transplantation of multipotent hematopoietic stem cells usually derived from bone marrow peripheral blood or umbilical cord blood.

Autologous hematopoietic stem cell transplantation hsct. Autologous hematopoietic stem cell transplantation hsct has been used as a therapy for severe and treatment refractory autoimmune diseases. Autologous hematopoietic stem cell transplant ahsct is the process of transplanting hematopoietic stem cells hscs cells in the bone marrow from which all kinds of blood cells such as red blood cells white blood cells and platelets originate into patients so their body can create new and healthy blood cells to compensate for their loss in diseases such as multiple myeloma. Autologous hematopoietic cell transplantation hct is the intravenous infusion of hematopoietic stem and progenitor cells designed to re establish marrow and immune function in patients with a.

It may be autologous the patient s own stem cells are used allogeneic the stem cells come from a donor or syngeneic from an identical twin. In hsct for ms hematopoietic blood cell producing stem cells which are derived from a person s own scientifically referred to as autologous bone marrow or blood are collected and stored prior to depleting much of the. It is most often performed for patients with certain cancers.

To determine if autologous nonmyeloablative hematopoietic stem cell transplantation hsct could be a salvage therapy for neuromyelitis optica spectrum disorder nmosd. Autologous haematopoietic stem cell transplantation ahsct if you wish to find out whether you may be suitable for this treatment please read the information on this website carefully. Hsct hematopoietic stem cell transplantation attempts to reboot the immune system which is responsible for damaging the brain and spinal cord in ms.

Thirteen patients were enrolled in a prospective open label cohort study 11 nmosd aquaporin 4 immunoglobulin g aqp4 igg positive 1 nmosd without aqp4 and 1 nmosd aqp4 igg positive with neuropsychiatric. If after reading this information and discussing it with your ms team you still feel that the treatment may be helpful you need to talk to your own neurologist or gp about a referral. Hematopoietic stem cell transplantation is approved for use in treating some types of cancer and is an experimental treatment for autoimmune diseases.

The premise for hsct is the de novo generation of naïve b and t cells which thereby resets the immunologic clock and reestablishes immune tolerance. The image below illustrates an algorithm for typically preferred hematopoietic stem cell transplantation cel.